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KMID : 0379520040200010013
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한국독성학회지
2004 Volume.20 No. 1 p.13 ~ p.20
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Comparative Biocompatibility of Metal Implants in Connective Tissue of Abdominal Wall of the Mouse
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Kim Kuk-Ryul
Lee Min-Ho
Kim Byung-Il
Min Byung-Woon
Kim Myung-Hoon
Choi Eun-Sang
Cho Hyun-Wook
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Abstract
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The purpose of this study is to compare the biocompatibility of commercial purity Ti, Ti-6AI-4V and Ti-6AI-7Nb alloy specimens with and without surface treatment in mouse abdominal connective tissue in vivo. Each metal was implanted into specific abdominal subdermal tissue site of female mouse. After 4 weeks, the implants were removed and abdominal tissues were fixed, dehydrated and embedded in glycol methacrylate resin. And the tissues were histologically prepared for microscopical evaluation. It was characterized by the presence of connective tissue with fibrous capsule surrounding the implant. The fibrous tissue surrounding the implant was studied to determine the biocompatibility of implanted metals. The average thickness of the fibrous capsule formed around the implant was much thinner for the hydrogen peroxide added hydrochloric acid solution-treated specimen than for the others. The results of this evaluation indicate that modification of the surface properties of titanium and titanium alloy implants changes the biological properties in the abdominal connective tissue. In conclusion, these observations suggest that the proper surface treatment performed in the study is effective for the improvement of biocompatibility.
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KEYWORD
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Biocompatibility, Abdominal wall, Titanium, Surface treatment.
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